Randal R. Ketchem Vcard Photo of Randal R. Ketchem

Randal R. Ketchem, Ph.D.

Vice President of Molecular Design
Just Biotherapeutics
Seattle, WA


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Objective

To utilize my skills and experience in computational structural biology, protein and antibody engineering and optimization, and team based therapeutic development to aid in the discovery of cures for and treatment of illness and disease.

Interests

Engineering biologics-based therapeutics, inventing novel therapeutic modalities and computational methods for therapeutic design, and computational and experimental approaches to understanding and controlling biophysical properties of biological macromolecules. Research direction focused on computational structural biology while also applying skills to broader platform review and direction. Working in areas of antibody design, epitope mapping, molecular assessment, stability engineering, construct design, protein structure analysis, protein engineering, and working with therapeutic area teams to lead target development.

  • Computational structural biology
  • Antibody design
  • Protein stability engineering
  • Therapeutic development
  • Protein structure analysis
  • Expert user of the Molecular Operating Environment
  • Project team environments
  • Computational and experimental approaches to understanding and controlling biophysical properties of biological macromolecules

Publications

Peer Reviewed:

  1. Intermolecular interactions involving an acidic patch on immunoglobulin variable domain and the γ2 constant region mediate crystalline inclusion body formation in the endoplasmic reticulum
    Haruki Hasegawa, Mei Genga, Randal R. Ketchem, Ling Liu, Kevin Graham, and Frederick Jacobsen
    Cellular Logistics 7(3), 2017

  2. A rare IL33 loss-of-function mutation reduces blood eosinophil counts and protects from asthma
    Dirk Smith, Hannes Helgason, Patrick Sulem, Unnur Steina Bjornsdottir, Ai Ching Lim, Gardar Sveinbjornsson, Haruki Hasegawa, Michael Brown, Randal R. Ketchem, Monica Gavala, Logan Garrett, Adalbjorg Jonasdottir, Aslaug Jonasdottir, Asgeir Sigurdsson, Olafur T. Magnusson, Gudmundur I. Eyjolfsson, Isleifur Olafsson, Pall Torfi Onundarson, Olof Sigurdardottir, David Gislason, Thorarinn Gislason, Bjorn Runar Ludviksson, Dora Ludviksdottir, H. Marike Boezen, Andrea Heinzmann, Marcus Krueger, Celeste Porsbjerg, Tarunveer S. Ahluwalia, Johannes Waage, Vibeke Backer, Klaus A. Deichmann, Gerard H. Koppelman, Klaus Bønnelykke, Hans Bisgaard,, Gisli Masson, Unnur Thorsteinsdottir, Daniel F. Gudbjartsson, James A. Johnston, Ingileif Jonsdottir, Kari Stefansson
    PLoS Genet 13(3), 2017

  3. Anti-PCSK9 Antibody Pharmacokinetics and Low-Density Lipoprotein-Cholesterol Pharmacodynamics in Nonhuman Primates Are Antigen Affinity-Dependent and Exhibit Limited Sensitivity to Neonatal Fc Receptor-Binding Enhancement
    Kirk R. Henne, Brandon Ason, Monique Howard, Wei Wang, Jeonghoon Sun, Jared Higbee, Jie Tang, Katherine C. Matsuda, Ren Xu, Lei Zhou, Joyce C. Y. Chan, Chadwick King, Derek E. Piper, Randal R. Ketchem, Mark Leo Michaels, Simon M. Jackson, and Marc W. Retter
    J Pharmacol Exp Ther, 353:119-131, April 2015

  4. ADAM8 as a drug target in pancreatic cancer
    Uwe Schlomann, Garrit Koller, Catharina Conrad, Taheera Ferdous, Panagiota Golfi, Adolfo Molejon Garcia, Sabrina Hoefling, Maddy Parsons, Patricia Costa, Robin Soper, Maud Bossard, Thorsten Hagemann, Rozita Roshani, Norbert Sewald, Randal R. Ketchem, Marcia L. Moss, Fred H. Rasmussen, Miles A. Miller, Douglas A. Lauffenburger, David A. Tuveson, Christopher Nimsky & Joerg W. Bartsch
    Nature Communications, 6175, 2015

  5. Remediating Agitation-Induced Antibody Aggregation by Eradicating Exposed Hydrophobic Motifs
    Rutilio H. Clark, Ramil F. Latypov, Cyr De Imus, Jane Carter, Zien Wilson, Kathy Manchulenko, Michael E. Brown, Randal R. Ketchem
    mAbs, 6:6, 1540-1550, 2014

  6. Entanglement Model of Antibody Viscosity
    Jeremy D. Schmit, Feng He, Shradha Mishra, Randal R. Ketchem, Christopher E. Woods and Bruce A. Kerwin
    The Journal of Physical Chemistry B, 118 (19), pp 5044-5049, 2014

  7. Small-Angle Neutron Scattering Study of a Monoclonal Antibody Using Free-Energy Constraints
    Nicholas J. Clark, Hailiang Zhang, Susan Krueger, Hyo Jin Lee, Randal R. Ketchem, Bruce Kerwin, Sekhar R. Kanapuram, Michael J. Treuheit, Arnold McAuley, and Joseph E. Curtis
    The Journal of Physical Chemistry B, 117 (45), pp 14029-14038, 2013

  8. Native-state solubility and transfer free energy as predictive tools for selecting excipients to include in protein formulation development studies
    Douglas D. Banks, Ramil F. Latypov, Randal R. Ketchem, Jon Woodard, Joanna L. Scavezze, Christine C. Siska, Vladimir I. Razinkov
    Journal of Pharmaceutical Sciences, v101, n8, p2720, 2012

  9. Chemical Modifications in Therapeutic Protein Aggregates Generated under Different Stress Conditions
    Quanzhou Luo, Marisa K. Joubert, Riki Stevenson, Randal R. Ketchem, Linda O. Narhi, and Jette Wypych
    The Journal of Biological Chemistry, v286, 25134-25144, 2011

  10. In Vivo Crystallization of Human IgG in the Endoplasmic Reticulum of Engineered Chinese Hamster Ovary (CHO) Cells
    Haruki Hasegawa, John Wendling, Feng He, Egor Trilisky, Riki Stevenson, Heather Franey, Francis Kinderman, Gary Li, Deirdre Murphy Piedmonte, Timothy Osslund, Min Shen, Randal R. Ketchem
    The Journal of Biological Chemistry, v286, 19917-19931, 2011

  11. Diverse functions of reactive cysteines facilitate unique biosynthetic processes of aggregate-prone interleukin-31
    Min Shen, Sophia Siu, Samantha Byrd, Kurt H. Edelmann, Neha Patel, Randal R. Ketchem, Christopher Mehlin, Heather A. Arnett, Haruki Hasegawa
    Experimental Cell Research, v317, 976-993, 2011

  12. Histidine Residue Mediates Radical-induced Hinge Cleavage of Human IgG1
    Zac Yates, Guna Kannan, Hongxing Zhou, Zhonghua Hu, Zhi Liu, Randal R. Ketchem, and Boxu Yan
    J. Biol. Chem., v285, n24, 18662-18671, 2010

  13. Glutamine-linked and Non-consensus Asparagine-linked Oligosaccharides Present in Human Recombinant Antibodies Define Novel Protein Glycosylation Motifs
    John F. Valliere-Douglass, Catherine M. Eakin, Alison Wallace, Randal R. Ketchem, Wesley Wang, Michael J. Treuheit, and Alain Balland
    J. Biol. Chem., v285, n21, 16012-16022, 2010

  14. A Diversity of Antibody Epitopes can Induce Signaling through the Erythropoietin Receptor
    Ai Ching Lim, Randal R Ketchem, Luis Borges, Teresa Carabeo, Jane Carter, Joseph E. Hoover, Zhonghua Hu, Michael Wittekind, Hongxing Zhou and Christopher Mehlin
    Biochemistry, v49, 3797-3804, 2010

  15. A Central Nervous System-Restricted Isoform of the Interleukin-1 Receptor Accessory Protein Modulates Neuronal Responses to Interleukin-1
    Dirk E. Smith, Brian P. Lipsky, Chris Russell, Randal R. Ketchem, Jacqueline Kirchner, Kelly Hensley, Yangyang Huang, Wilma J. Friedman, Vincent Boissonneault, Marie-Michèle Plante, Serge Rivest and John E. Sims
    Immunity, v30, n6, 817-831, 2009

  16. Electrophoretic evidence for the presence of structural isoforms specific for the IgG2 isotype
    Amy Guo, Mei Han, Theresa Martinez, Randal R. Ketchem, Shawn Novick, Claudia Jochheim, Alain Balland
    Electrophoresis, 29, 2550-2556, 2008

  17. A role for the MHC class I-like Mill molecules in nutrient metabolism and wound healing
    Brian A. Rabinovich, Randal R. Ketchem, Martin Wolfson, Lynn Goldstein, Marylin Skelly and David Cosman
    Immunology and Cell Biology, v86, 489-496, 2008

  18. Disulfide Connectivity of Human Immunoglobulin G2 Structural Isoforms
    Theresa Martinez, Amy Guo, Martin J. Allen, Mei Han, Danielle Pace, Jay Jones, Ron Gillespie, Randal R. Ketchem, Yuling Zhang, and Alain Balland
    Biochemistry, v47, 7496-7508, 2008

  19. Biophysical Characterization of Structural Properties and Folding of Interleukin-1 Receptor Antagonist
    Ramil F. Latypov, Timothy S. Harvey, Dingjiang Liu, Pavel V. Bondarenko, Tadahiko Kohno, Roger A. Fachini II, Robert D. Rosenfeld, Randal R. Ketchem, David N. Brems, and Andrei A. Raibekas
    Journal of Molecular Biology, v368, 1187-1201, 2007

  20. A Single Amino Acid Difference between Human and Monkey Interleukin (IL)-1B Dictates Effective Binding to Soluble Type II IL-1 Receptor
    Dirk E. Smith, Randal R. Ketchem, Heather Moore, Zachary Anderson, Blair R. Renshaw, Della J. Friend, and John E. Sims
    The Journal of Biological Chemistry, v277, n49, 47619-47625, 2002

  21. Biophysical Characterization of a Soluble CD40 Ligand (CD154) Coiled-Coil Trimer: Evidence of a Reversible Acid-Denatured Molten Globule
    James E. Matsuura, Arvia E. Morris, Randal R. Ketchem, Emory H. Braswell, Ralph Klinke, Wayne R. Gombotz, and Richard L. Remmele, Jr.
    Archives of Biochemistry and Biophysics, v392, n2, 208-218, 2001

  22. Four New Members Expand the Interleukin-1 Superfamily
    Dirk E. Smith, Blair R. Renshaw, Randal R. Ketchem, Marek Kubin, Kirsten E. Garka, and John E. Sims
    The Journal of Biological Chemistry, v275, n2, 1169-1175, 2000

  23. Binding-Induced Activation of DNA Alkylation by Duocarmycin SA: Insights from the Structure of an Indole Derivative-DNA Adduct
    Jason R. Schnell, Randal R. Ketchem, Dale L. Boger, and Walter J. Chazin
    Journal of the American Chemical Society, v121, 5645-5652, 1999

  24. The three-dimensional structure of Ca2+-bound calcyclin: implications for Ca2+-signal transduction by S100 proteins
    Mallika Sastry, Randal R Ketchem, Orlando Crescenzi, Christoph Weber, Michael J Lubienski, Hiroyoshi Hidaka and Walter J Chazin
    Structure, v6, 223-231, 1998

  25. High-resolution polypeptide structure in a lamellar phase lipid environment from solid state NMR derived orientational constraints
    RR Ketchem, B Roux and TA Cross
    Structure, v5, 1655-1669, 1997

  26. Macromolecular structural elucidation with solid-state NMR-derived orientational constraints
    R. R. Ketchem, K. -C. Lee, S. Huo, and T. A. Cross
    Journal of Biomolecular NMR, v8,1-14, 1996

  27. Conformational trapping in a membrane environment: A regulatory mechanism for protein activity?
    S. Arumugam, S. Pascal, C. L. North, W. Hu, K-C. Lee, M. Cotten, R. R. Ketchem, F. Xu, M. Brenneman, F. Kovacs, F. Tian, A. Wang, S. Huo, and T. A. Cross
    Proceedings of the National Academy of Sciences of the United States of America, v93, 5872-5876, 1996

  28. High-Resolution Conformation of Gramicidin A in a Lipid Bilayer by Solid-State NMR
    R. R. Ketchem, W. Hu, T. A. Cross
    Science, v261, 1457-1460, 1993


Invited:

  1. Best Practices in Developability Assessments of Therapeutic Protein Candidates in the Biopharmaceutical Industry
    Nicolas Angell, Randal R. Ketchem, Kristine Daris, Jason W. O’Neill, and Kannan Gunasekaran
    Developability of Biotherapeutics: Computational Approaches, Sandeep Kumar, Satish Kumar Singh, CRC Press, 2015

  2. Computational Refinement Through Solid State NMR and Energy Constraints of a Membrane Bound Polypeptide.
    R.R. Ketchem, B. Roux and T.A. Cross
    Biological Membranes: A Molecular Perspective from Computation and Experiment, K.M. Merz and B. Roux, Birkhauser Boston, 1996

  3. Structure and dynamics from solid state NMR spectroscopy
    RR Ketchem, W Hu, F Tian and TA Cross
    Structure, v2, 699-701, 1994

  4. High Resolution Polypeptide Structure in Anisotropic Environments: The Gramicidin Channel
    T.A. Cross, R.R. Ketchem, W. Hu, K.C. Lee, N.D. Lazo and S. Huo
    Proceedings of the Conference on Stable Isotope Applications in Biomolecular Structure and Mechanisms, 1994

  5. Structure and Dynamics of a Membrane Bound Polypeptide
    T.A. Cross, R.R. Ketchem, W. Hu, K.C. Lee, N.D. Lazo and C.L. North
    Bulletin of Magnetic Resonance v14, 96-101, 1993
    PDF of paper.


Patents Issued:

  1. Variant Fc-polypeptides with enhanced binding to the neonatal Fc receptor
    Filed: December 17, 2012
    Issued: June 27, 2017
    Inventors: Sun, Jeonghoon; Han, Seog Joon; Harris, Susie M; Ketchem, Randal R; Lu, Ji; Michaels, Mark L; Retter, Marc W; Tsai, Mei-Mei
    United States Patent 9,688,756
    PDF of issued patent.

  2. Antigen binding proteins to proprotein convertase subtilisin kexin type 9 (PCSK9)
    Filed: August 14, 2014
    Issued: November 15, 2016
    Inventors: Jackson, Simon Mark; Walker, Nigel Pelham Clinton; Piper, Derek Evan; Shan, Bei; Shen, Wenyan; King, Chadwick Terence; Ketchem, Randal Robert; Mehlin, Christopher; Carabeo, Teresa Arazas
    United States Patent 9,493,576
    PDF of issued patent.

  3. Human IL-23 antigen binding proteins
    Filed: March 28, 2014
    Issued: November 8, 2016
    Inventors: Towne, Jennifer E., Cheng, Janet D.; O'Neill, Jason C.; Zhang, Yu; Sun, Yu; Cerne, Heather; Piper, Derek E.; Ketchem, Randal R.
    United States Patent 9,487,580
    PDF of issued patent.

  4. GITR antigen binding proteins and methods of use thereof
    Filed: August 28, 2014
    Issued: October 11, 2016
    Inventors: Beers, Courtney; O'Neill, Jason C.; Foltz, Ian; Ketchem, Randal R.; Piasecki, Julia C.
    United States Patent 9,464,139
    PDF of issued patent.

  5. ST2 antigen binding proteins
    Filed: May 17, 2013
    Issued: July 5, 2016
    Inventors: Smith, Dirk E.; Foltz, Ian; King, Chadwick T.; Lim, Ai Ching; Clark, Rutilio; Comeau, Michael R.; Ketchem, Randal R.; Shi, Donghui; Min, Xiaoshan; Wang, Zhulun
    United States Patent 9,382,318
    PDF of issued patent.

  6. Anti-hepcidin antibodies and methods of use
    Filed: April 28, 2009
    Issued: April 19, 2016
    Inventors: Foltz, Ian; Gallo, Michael; Cooke, Keegan; Ketchem, Randal R.; Mehlin, Christopher
    United States Patent 9,315,577
    PDF of issued patent.

  7. Antigen binding proteins to proprotein convertase subtilisin kexin type 9 (PCSK9)
    Filed: August 14, 2014
    Issued: June 16, 2015
    Inventors: Jackson, Simon Mark; Walker, Nigel Pelham Clinton; Piper, Derek Evan; Shan, Bei; Shen, Wenyan; King, Chadwick Terence; Ketchem, Randal Robert; Mehlin, Christopher; Carabeo, Teresa Arazas
    United States Patent 9,056,915
    PDF of issued patent.

  8. Methods of using antigen binding proteins to proprotein convertase subtilisin kexin type 9 (PCSK9)
    Filed: October 3, 2011
    Issued: June 2, 2015
    Inventors: Jackson, Simon Mark; Walker, Nigel Pelham Clinton; Piper, Derek Evan; Shan, Bei; Shen, Wenyan; Chan, Joyce Chi Yee; King, Chadwick Terence; Ketchem, Randal Robert; Mehlin, Christopher; Carabeo, Teresa Arazas
    United States Patent 9,045,547
    PDF of issued patent.

  9. Antigen binding proteins to proprotein convertase subtilisin kexin type 9 (PCSK9)
    Filed: August 14, 2014
    Issued: March 17, 2015
    Inventors: Jackson, Simon Mark; Shan, Bei; Shen, Wenyan; King, Chadwick Terence; Ketchem, Randal Robert; Mehlin, Christopher; Carabeo, Teresa Arazas
    United States Patent 8,981,064
    PDF of issued patent.

  10. Antigen binding proteins to proprotein convertase subtilisin kexin type 9 (PCSK9)
    Filed: April 24, 2014
    Issued: November 18, 2014
    Inventors: Jackson, Simon Mark; Walker, Nigel Pelham Clinton; Piper, Derek Evan; Shen, Wenyan; King, Chadwick Terence; Ketchem, Randal Robert; Mehlin, Christopher; Carabeo, Teresa Arazas
    United States Patent 8,889,834
    PDF of issued patent.

  11. Antigen binding proteins to proprotein convertase subtilisin kexin type 9 (PCSK9)
    Filed: April 24, 2014
    Issued: November 11, 2014
    Inventors: Jackson, Simon Mark; Walker, Nigel Pelham Clinton; Piper, Derek Evan; Shen, Wenyan; King, Chadwick Terence; Ketchem, Randal Robert; Mehlin, Christopher; Carabeo, Teresa Arazas
    United States Patent 8,883,983
    PDF of issued patent.

  12. Antigen binding proteins to proprotein convertase subtilisin kexin type 9 (PCSK9)
    Filed: April 24, 2014
    Issued: October 28, 2014
    Inventors: Jackson, Simon Mark; Walker, Nigel Pelham Clinton; Piper, Derek Evan; Shen, Wenyan; King, Chadwick Terence; Ketchem, Randal Robert; Mehlin, Christopher; Carabeo, Teresa Arazas
    United States Patent 8,871,914
    PDF of issued patent.

  13. Antigen binding proteins to proprotein convertase subtilisin kexin type 9 (PCSK9)
    Filed: April 24, 2014
    Issued: October 28, 2014
    Inventors: Jackson, Simon Mark; Walker, Nigel Pelham Clinton; Piper, Derek Evan; Shen, Wenyan; King, Chadwick Terence; Ketchem, Randal Robert; Mehlin, Christopher; Carabeo, Teresa Arazas
    United States Patent 8,871,913
    PDF of issued patent.

  14. IL-1F8 polypeptides
    Filed: June 11, 2013
    Issued: October 28, 2014
    Inventors: Sims, John E.; Renshaw, Blair R.; Gabel, Christopher; Towne, Jennifer E.; Ketchem, Randal R.
    United States Patent 8,871,192
    PDF of issued patent.

  15. Antigen binding proteins to proprotein convertase subtilisin kexin type 9 (PCSK9)
    Filed: April 24, 2014
    Issued: October 14, 2014
    Inventors: Jackson, Simon Mark; Walker, Nigel Pelham Clinton; Piper, Derek Evan; Shen, Wenyan; King, Chadwick Terence; Ketchem, Randal Robert; Mehlin, Christopher; Carabeo, Teresa Arazas
    United States Patent 8,859,741
    PDF of issued patent.

  16. Antigen binding proteins to proprotein convertase subtilisin kexin type 9 (PCSK9)
    Filed: April 10, 2013
    Issued: September 9, 2014
    Inventors: Jackson, Simon Mark; Walker, Nigel Pelham Clinton; Piper, Derek Evan; Shen, Wenyan; King, Chadwick Terence; Ketchem, Randal Robert; Mehlin, Christopher; Carabeo, Teresa Arazas
    United States Patent 8,829,165
    PDF of issued patent.

  17. Human IL-23 antigen binding proteins
    Filed: Sep 9, 2010
    Issued: May 13, 2014
    Inventors: Towne, Jennifer E.; Cheng, Janet D.; O'Neill, Jason C.; Zhang, Yu; Sun, Yu; Cerne, Heather; Piper, Derek E.; Ketchem, Randal R.
    United States Patent 8,722,033
    PDF of issued patent.

  18. Antigen binding proteins to proprotein convertase subtilisin kexin type 9 (PCSK9)
    Filed: May 28, 2009
    Issued: October 22, 2013
    Inventors: Jackson, Simon Mark; Walker, Nigel Pelham Clinton; Piper, Derek Evan; Shen, Wenyan; King, Chadwick Terence; Ketchem, Randal Robert; Mehlin, Christopher; Carabeo, Teresa Arazas
    United States Patent 8,563,698
    PDF of issued patent.

  19. IL-1F5 Polypeptides
    Filed: September 2, 2011
    Issued: July 9, 2013
    Inventors: Sims, John E.; Renshaw, Blair R.; Gabel, Christopher; Towne, Jennifer E.; Ketchem, Randal R.
    United States Patent 8,481,021
    PDF of issued patent.

  20. Tweak receptor
    Filed: October 6, 2010
    Issued: April 9, 2013
    Inventors: Kim, Kristine M.; Wiley, Steven R.; Ketchem, Randal R.; Fanslow, III, William C.
    United States Patent 8,414,895
    PDF of issued patent.

  21. IL-1F6 Polypeptides
    Filed: September 10, 2007
    Issued: October 11, 2011
    Inventors: Sims, John E.; Renshaw, Blair R.; Gabel, Christopher; Towne, Jennifer E.; Ketchem, Randal R.
    United States Patent 8,034,771
    PDF of issued patent.

  22. TWEAK receptor
    Filed: January 16, 2009
    Issued: November 9, 2010
    Inventors: Kim, Kristine M.; Wiley, Steven R.; Ketchem, Randal R.; Fanslow, III, William C.
    United States Patent 7,829,675
    PDF of issued patent.

  23. TRAIL Receptor-2 Polypeptides and antibodies
    Published: August 2, 2007
    Issued: April 21, 2009
    Inventors: Gliniak, Brian; Yang, Xiao-Dong; Wong-Madden, Sharon; Foltz, Ian; Feng, Xiao; Fitch, Alison; Foster, Stephen; Ketchem, Randal R.
    United States Patent 7,521,048
    PDF of issued patent.

  24. TWEAK receptor
    Published: September 22, 2005
    Issued: February 24, 2009
    Inventors: Kim, Kristine M.; Wiley, Steven R.; Ketchem, Randal R.; Fanslow, William C. III
    United States Patent 7,495,086
    PDF of issued patent.


Patents Published:

  1. DIRECT SELECTION OF CELLS EXPRESSING HIGH LEVELS OF HETEROMERIC PROTEINS USING GLUTAMINE SYNTHETASE INTRAGENIC COMPLEMENTATION VECTORS
    Filing Date: May 11, 2017
    Publication Date: November 16, 2017
    Inventors: Ketchem, Randal R.; McGrew, Jeffrey T.; Fomina Yadlin, Dina A.; Munro, Trent P.; Agrawal, Neeraj Jagdish; Daris, Kristine M.
    WIPO Patent Application: WO/2017/197098
    PDF of patent application.

  2. ST2 ANTIGEN BINDING PROTEINS
    Filing Date: May 22, 2017
    Publication Date: September 21, 2017
    Inventors: Smith, Dirk E.; Foltz, Ian; King, Chadwick T.; Lim, Ai Ching; Clark, Rutilio; Comeau, Michael R.; Ketchem, Randal R.; Shi, Donghui; Min, Xiaoshan; Wang, Zhulun
    United States Patent Application: 20170267769
    PDF of patent application.

  3. GITR ANTIGEN BINDING PROTEINS
    Filing Date: October 10, 2016
    Publication Date: January 26, 2017
    Inventors: Beers, Courtney; O'Neill, Jason C.; Foltz, Ian; Ketchem, Randall R.; Piasecki, Julia C.
    United States Patent Application: 20170022285
    PDF of patent application.

  4. HUMAN IL-23 ANTIGEN BINDING PROTEINS
    Filing Date: September 21, 2016
    Publication Date: January 5, 2017
    Inventors: Towne, Jennifer E.; Cheng, Janet D.; O'Neill, Jason C.; Zhang, Yu; Sun, Yu; Cerne, Heather; Piper, Derek E.; Ketchem, Randal R.
    United States Patent Application: 20170002070
    PDF of patent application.

  5. ST2 ANTIGEN BINDING PROTEINS
    Filing Date: June 10, 2016
    Publication Date: January 5, 2017
    Inventors: Smith, Dirk E.; Foltz, Ian; King, Chadwick T.; Lim, Ai Ching; Clark, Rutilio; Comeau, Michael R.; Ketchem, Randal R.; Shi, Donghui; Min, Xiaoshan; Wang, Zhulun
    United States Patent Application: 20170002079
    PDF of patent application.

  6. INTERLEUKIN-2 MUTEINS FOR THE EXPANSION OF T-REGULATORY CELLS
    Filing Date: May 4, 2016
    Publication Date: October 13, 2016
    Inventors: Butz, Eric Alan; Thomson, Christy Ann; Gavin, Marc Alain; Foltz, Ian Nevin; Xia, Dong; Alcorn, Dina N.; Lim, Ai Ching; Ketchem, Randal Robert; Manchulenko, Kathy; Sekirov, Laura; Berry, Kelly Ann; De Imus, Cyr Clovis Chua; Agrawal, Neeraj Jagdish; Kannan, Gunasekaran
    WIPO Patent Application: WO/2016/164937
    PDF of patent application.

  7. FC-CONTAINING MOLECULES EXHIBITING PREDICTABLE, CONSISTENT, AND REPRODUCIBLE GLYCOFORM PROFILES
    Filing Date: September 5, 2014
    Publication Date: July 21, 2016
    Inventors: Du, Zhimei; Reddy, Pranhitha; Bass, Randal B.; He, Feng; Fanslow, III, William C.; Zhang, Yuling; Ren, Da; Ketchem, Randal R.
    United States Patent Application: 20160207980
    PDF of patent application.

  8. HUMAN ANTIGEN BINDING PROTEINS THAT BIND TO PROPROTEIN CONVERTASE SUBTILISIN KEXIN TYPE 9
    Filing Date: March 14, 2014
    Publication Date: February 4, 2016
    Inventors: Michaels, Mark Leo; Ketchem, Randal R.; Piper, Derek E.; Yan, Wei; King, Chadwick Terence; Howard, Monique LaRae
    United States Patent Application: 20160032014
    PDF of patent application.

  9. VARIANTS OF TISSUE INHIBITOR OF METALLOPROTEINASE TYPE THREE (TIMP-3), COMPOSITIONS AND METHODS
    Filing Date: March 13, 2014
    Publication Date: February 4, 2016
    Inventors: Sun, Jeonghoon; O'Neill, Jason Charles; Ketchem, Randal R.; Hecht, Randy Ira; Belouski, Edward J.; Michaels, Mark Leo
    United States Patent Application: 20160031969
    PDF of patent application.

  10. ANTIGEN BINDING PROTEINS TO PROPROTEIN CONVERTASE SUBTILISIN KEXIN TYPE 9 (PCSK9)
    Filing Date: December 5, 2014
    Publication Date: March 26, 2015
    Inventors: Jackson, Simon Mark; Walker, Nigel Pelham Clinton; Piper, Derek Evan; Shan, Bei; Shen, Wenyan; Chan, Joyce Chi Yee; King, Chadwick Terence; Ketchem, Randal Robert; Mehlin, Christopher; Carabeo, Teresa Arazas; Cao, Qiong
    United States Patent Application: 20150087819
    PDF of patent application.

  11. GITR ANTIGEN BINDING PROTEINS
    Filing Date: August 28, 2014
    Publication Date: March 5, 2015
    Inventors: Beers, Courtney; O'Neill, Jason C.; Foltz, Ian; Ketchem, Randal R.; Piasecki, Julia C.
    United States Patent Application: 20150064204
    PDF of patent application.

  12. ANTIGEN BINDING PROTEINS TO PROPROTEIN CONVERTASE SUBTILISIN KEXIN TYPE 9 (PCSK9)
    Filing Date: September 16, 2014
    Publication Date: January 29, 2015
    Inventors: Jackson, Simon Mark; Walker, Nigel Pelham Clinton; Piper, Derek Evan; Shen, Wenyan; King, Chadwick Terence; Ketchem, Randal Robert; Mehlin, Christopher; Carabeo, Teresa Arazas
    United States Patent Application: 20150031870
    PDF of patent application.

  13. IL-1 FAMILY VARIANTS
    Filing Date: September 22, 2014
    Publication Date: January 15, 2015
    Inventors: Sims, John E.; Renshaw, Blair R.; Gabel, Christopher; Towne, Jennifer E.; Ketchem, Randal R.
    United States Patent Application: 20150017123
    PDF of patent application.

  14. NUCLEIC ACID ENCODING ANTIGEN BINDING PROTEINS TO PROPROTEIN CONVERTASE SUBTILISIN KEXIN TYPE 9 (PCSK9)
    Filing Date: August 14, 2014
    Publication Date: December 4, 2014
    Inventors: Jackson, Simon Mark; Walker, Nigel Pelham Clinton; Piper, Derek Evan; Shan, Bei; Shen, Wenyan; Chan, Joyce Chi Yee; King, Chadwick Terence; Ketchem, Randal Robert; Mehlin, Christopher; Carabeo, Teresa Arazas; Cao, Qiong
    United States Patent Application: 20140357854
    PDF of patent application.

  15. NUCLEIC ACID ENCODING ANTIGEN BINDING PROTEINS TO PROPROTEIN CONVERTASE SUBTILISIN KEXIN TYPE 9 (PCSK9)
    Filing Date: August 14, 2014
    Publication Date: December 4, 2014
    Inventors: Jackson, Simon Mark; Walker, Nigel Pelham Clinton; Piper, Derek Evan; Shan, Bei; Shen, Wenyan; Chan, Joyce Chi Yee; King, Chadwick Terence; Ketchem, Randal Robert; Mehlin, Christopher; Carabeo, Teresa Arazas; Cao, Qiong
    United States Patent Application: 20140357853
    PDF of patent application.

  16. NUCLEIC ACID ENCODING ANTIGEN BINDING PROTEINS TO PROPROTEIN CONVERTASE SUBTILISIN KEXIN TYPE 9 (PCSK9)
    Filing Date: August 14, 2014
    Publication Date: December 4, 2014
    Inventors: Jackson, Simon Mark; Walker, Nigel Pelham Clinton; Piper, Derek Evan; Shan, Bei; Shen, Wenyan; Chan, Joyce Chi Yee; King, Chadwick Terence; Ketchem, Randal Robert; Mehlin, Christopher; Carabeo, Teresa Arazas; Cao, Qiong
    United States Patent Application: 20140357852
    PDF of patent application.

  17. NUCLEIC ACID ENCODING ANTIGEN BINDING PROTEINS TO PROPROTEIN CONVERTASE SUBTILISIN KEXIN TYPE 9 (PCSK9)
    Filing Date: August 14, 2014
    Publication Date: December 4, 2014
    Inventors: Jackson, Simon Mark; Walker, Nigel Pelham Clinton; Piper, Derek Evan; Shan, Bei; Shen, Wenyan; Chan, Joyce Chi Yee; King, Chadwick Terence; Ketchem, Randal Robert; Mehlin, Christopher; Carabeo, Teresa Arazas; Cao, Qiong
    United States Patent Application: 20140357851
    PDF of patent application.

  18. NUCLEIC ACID ENCODING ANTIGEN BINDING PROTEINS TO PROPROTEIN CONVERTASE SUBTILISIN KEXIN TYPE 9 (PCSK9)
    Filing Date: August 14, 2014
    Publication Date: December 4, 2014
    Inventors: Jackson, Simon Mark; Walker, Nigel Pelham Clinton; Piper, Derek Evan; Shan, Bei; Shen, Wenyan; Chan, Joyce Chi Yee; King, Chadwick Terence; Ketchem, Randal Robert; Mehlin, Christopher; Carabeo, Teresa Arazas; Cao, Qiong
    United States Patent Application: 20140357850
    PDF of patent application.

  19. VARIANT FC-POLYPEPTIDES WITH ENHANCED BINDING TO THE NEONATAL FC RECEPTOR
    Filing Date: December 17, 2012
    Publication Date: December 4, 2014
    Inventors: Sun, Jeonghoon; Han, Seog Joon; Harris, Susie M.; Ketchem, Randal R; Lu, Ji; Michaels, Mark L; Retter, Marc W; Tsai, Mei-Mei
    United States Patent Application: 20140356358
    PDF of patent application.

  20. VARIANTS OF TISSUE INHIBITOR OF METALLOPROTEINASE TYPE THREE (TIMP-3), COMPOSITIONS AND METHODS
    Filing Date: March 12, 2014
    Publication Date: September 18, 2014
    Inventors: Ketchem, Randal R.; O'Neill, Jason Charles; Sun, Jeonghoon
    United States Patent Application: 20140274874
    PDF of patent application.

  21. ANTIGEN BINDING PROTEINS TO PROPROTEIN CONVERTASE SUBTILISIN KEXIN TYPE 9 (PCSK9)
    Filing Date: April 24, 2014
    Publication Date: August 21, 2014
    Inventors: Jackson, Simon Mark; Walker, Nigel Pelham Clinton; Piper, Derek Evan; Shen, Wenyan; King, Chadwick Terence; Ketchem, Randal Robert; Mehlin, Christopher; Carabeo, Teresa Arazas
    United States Patent Application: 20140235830
    PDF of patent application.

  22. ANTIGEN BINDING PROTEINS TO PROPROTEIN CONVERTASE SUBTILISIN KEXIN TYPE 9 (PCSK9)
    Filing Date: April 24, 2014
    Publication Date: August 21, 2014
    Inventors: Jackson, Simon Mark; Walker, Nigel Pelham Clinton; Piper, Derek Evan; Shen, Wenyan; King, Chadwick Terence; Ketchem, Randal Robert; Mehlin, Christopher; Carabeo, Teresa Arazas
    United States Patent Application: 20140235831
    PDF of patent application.

  23. ANTIGEN BINDING PROTEINS TO PROPROTEIN CONVERTASE SUBTILISIN KEXIN TYPE 9 (PCSK9)
    Filing Date: April 24, 2014
    Publication Date: August 14, 2014
    Inventors: Jackson, Simon Mark; Walker, Nigel Pelham Clinton; Piper, Derek Evan; Shan, Bei; Shen, Wenyan; Chan, Joyce Chi Yee; King, Chadwick Terence; Ketchem, Randal Robert; Mehlin, Christopher; Carabeo, Teresa Arazas; Cao, Qiong
    United States Patent Application: 20140228545
    PDF of patent application.

  24. ANTIGEN BINDING PROTEINS TO PROPROTEIN CONVERTASE SUBTILISIN KEXIN TYPE 9 (PCSK9)
    Filing Date: April 24, 2014
    Publication Date: August 14, 2014
    Inventors: Jackson, Simon Mark; Walker, Nigel Pelham Clinton; Piper, Derek Evan; Shan, Bei; Shen, Wenyan; Chan, Joyce Chi Yee; King, Chadwick Terence; Ketchem, Randal Robert; Mehlin, Christopher; Carabeo, Teresa Arazas; Cao, Qiong
    United States Patent Application: 20140228547
    PDF of patent application.

  25. ANTIGEN BINDING PROTEINS TO PROPROTEIN CONVERTASE SUBTILISIN KEXIN TYPE 9 (PCSK9)
    Filing Date: April 24, 2014
    Publication Date: August 14, 2014
    Inventors: Jackson, Simon Mark; Walker, Nigel Pelham Clinton; Piper, Derek Evan; Shan, Bei; Shen, Wenyan; Chan, Joyce Chi Yee; King, Chadwick Terence; Ketchem, Randal Robert; Mehlin, Christopher; Carabeo, Teresa Arazas; Cao, Qiong
    United States Patent Application: 20140228557
    PDF of patent application.

  26. HUMAN IL-23 ANTIGEN BINDING PROTEINS
    Filing Date: March 28, 2014
    Publication Date: July 31, 2014
    Inventors: Towne, Jennifer E.; Cheng, Janet D.; O'Neill, Jason C.; Zhang, Yu; Sun, Yu; Cerne, Heather; Piper, Derek E.; Ketchem, Randal R.
    United States Patent Application: 20140212428
    PDF of patent application.

  27. ST2 ANTIGEN BINDING PROTEINS
    Filing Date: May 17, 2013
    Publication Date: January 2, 2014
    Inventors: Smith, Dirk E.; Foltz, Ian; King, Chadwick T.; Lim, Ai Ching; Clark, Rutilio; Comeau, Michael R.; Ketchem, Randal R.; Shi, Donghui; Min, Xiaoshan; Wang, Zhulun
    United States Patent Application: 20140004107
    PDF of patent application.

  28. IL-1 FAMILY VARIANTS
    Filing Date: 2013-06-11
    Publication Date: 2013-12-19
    Inventors: Sims, John E.; Renshaw, Blair R.; Gabel, Christopher; Towne, Jennifer E.; Ketchem; Randal R.
    United States Patent Application: 20130336926
    PDF of patent application.

  29. ANTIGEN BINDING PROTEINS TO PROPROTEIN CONVERTASE SUBTILISIN KEXIN TYPE 9 (PCSK9)
    Filing Date: April 10, 2013
    Publication Date: September 19, 2013
    Inventors: Jackson, Simon Mark; Walker, Nigel Pelham Clinton; Piper, Derek Evan; Shen, Wenyan; King, Chadwick Terence; Ketchem, Randal Robert; Mehlin, Christopher; Carabeo, Teresa Arazas
    United States Patent Application: 20130245235
    PDF of patent application.

  30. POLYPEPTIDES AND ANTIBODIES
    Filing Date: September 7, 2012
    Publication Date: April 25, 2013
    Inventors: Gliniak, Brian; Yang, Xiao-Dong; Wong-Madden, Sharon; Foltz, Ian; Feng, Xiao; Fitch, Alison; Foster, Stephen; Ketchem, Randal R.
    United States Patent Application: 20130101589
    PDF of patent application.

  31. ANTIGEN BINDING PROTEINS TO PROPROTEIN CONVERTASE SUBTILISIN KEXIN TYPE 9 (PCSK9)
    Filing Date: March 16, 2012
    Publication Date: April 4, 2013
    inventors: Jackson, Simon Mark; Walker, Nigel Pelham Clinton; Piper, Derek Evan; Shan, Bei; Shen, Wenyan; Chan, Joyce Chi Yee; King, Chadwick Terence; Ketchem, Randal Robert; Mehlin, Christopher; Carabeo, Teresa Arazas; Cao, Qiong
    United States Patent Application: 20130085265
    PDF of patent application.

  32. ANTIGEN BINDING PROTEINS TO PROPROTEIN CONVERTASE SUBTILISIN KEXIN TYPE 9 (PCSK9)
    Filing Date: March 16, 2012
    Publication Date: March 28, 2013
    inventors: Jackson, Simon Mark; Walker, Nigel Pelham Clinto; Piper, Derek Evan; Shan, Bei; Shen, Wenyan; Chan, Joyce Chi Yee; King, Chadwick Terence; Ketchem, Randal Robert; Mehlin, Christopher; Carabeo, Teresa Arazas; Cao, Qiong
    United States Patent Application: 20130079501
    PDF of patent application.

  33. ANTIGEN BINDING PROTEINS TO PROPROTEIN CONVERTASE SUBTILISIN KEXIN TYPE 9 (PCSK9)
    Filing Date: September 14, 2012
    Publication Date: March 21, 2013
    Inventors: Jackson, Simon Mark; Walker, Nigel Pelham Clinton; Piper, Derek Evan; Shan, Bei; Shen, Wenyan; Chan, Joyce Chi Yee; King, Chadwick Terrence; Ketchem, Randal Robert; Mehlin, Christopher; Carabeo, Teresa Arazas; Cao, Qiong
    United States Patent Application: 20130072665
    PDF of patent application.

  34. ANTIGEN BINDING PROTEINS TO PROPROTEIN CONVERTASE SUBTILISIN KEXIN TYPE 9 (PCSK9)
    Filing Date: October 19, 2012
    Publication Date: March 7, 2013
    Inventors: Jackson, Simon Mark; Walker, Nigel Pelham Clinton; Piper, Derek Evan; Shan, Bei; Shen, Wenyan; Chan, Joyce Chi Yee; King, Chadwick Terence; Ketchem, Randal Robert; Mehlin, Christopher; Carabeo, Teresa Arazas; Cao, Qiong
    United States Patent Application: 20130058944
    PDF of patent application.

  35. ANTIGEN BINDING PROTEINS TO PROPROTEIN CONVERTASE SUBTILISIN KEXIN TYPE 9 (PCSK9)
    Filing Date: October 19, 2012
    Publication Date: February 28, 2013
    Inventors: Jackson, Simon Mark; Walker, Nigel Pelham Clinton; Piper, Derek Evan; Shan, Bei; Shen, Wenyan; Chan, Joyce Chi Yee; King, Chadwick Terence; Ketchem, Randal Robert; Mehlin, Christopher; Carabeo, Teresa Arazas; Cao, Qiong
    United States Patent Application: 20130052201
    PDF of patent application.

  36. HUMAN IL-23 ANTIGEN BINDING PROTEINS
    Filing Date: October 26, 2010
    Publication Date: January 3, 2013
    Inventors: Towne, Jennifer E.; Cheng, Janet D.; O'Neill, Jason C.; Zhang, Yu; Sun, Yu; Cerne, Heather; Piper, Derek E.; Ketchem, Randal R.
    United States Patent Application: 20130004501
    PDF of patent application.

  37. ANTIGEN BINDING PROTEINS TO PROPROTEIN CONVERTASE SUBTILISIN KEXIN TYPE 9 (PCSK9)
    Filing Date: June 12, 2012
    Publication Date: October 4, 2012
    Inventors: Jackson, Simon Mark; Walker, Nigel Pelham Clinton; Piper, Derek Evan; Shan, Bei; Shen, Wenyan; Chan, Joyce Chi Yee; King, Chadwick Terence; Ketchem, Randal Robert; Mehlin, Christopher; Carabeo, Teresa Arazas; Cao, Qiong
    United States Patent Application: 20120251544
    PDF of patent application.

  38. ANTIGEN BINDING PROTEINS TO PROPROTEIN CONVERTASE SUBTILISIN KEXIN TYPE 9 (PCSK9)
    Filing Date: May 3, 2012
    Publication Date: August 23, 2012
    Inventors: Jackson, Simon Mark; Walker, Nigel Pelham Clinton; Piper, Derek Evan; Shan, Bei; Shen, Wenyan; Chan, Joyce Chi Yee; King, Chadwick Terence; Ketchem, Randal Robert; Mehlin, Christopher; Carabeo, Teresa Arazas; Cao, Qiong
    United States Patent Application: 20120213797
    PDF of patent application.

  39. ANTIGEN BINDING PROTEINS TO PROPROTEIN CONVERTASE SUBTILISIN KEXIN TYPE 9 (PCSK9)
    Filing Date: June 30, 2011
    Publication Date: April 19, 2012
    Inventors: Jackson, Simon Mark; Walker, Nigel Pelham Clinton; Piper, Derek Evan; Shan, Bei; Shen, Wenyan; Chan, Joyce Chi Yee; King, Chadwick Terence; Ketchem, Randal Robert; Mehlin, Christopher; Carabeo, Teresa Arazas; Cao, Qiong
    United States Patent Application: 20120093818
    PDF of patent application.

  40. ANTIGEN BINDING PROTEINS TO PROPROTEIN CONVERTASE SUBTILISIN KEXIN TYPE 9 (PCSK9)
    Filing Date: October 3, 2011
    Publication Date: February 2, 2012
    Inventors: Jackson, Simon Mark; Walker, Nigel Pelham Clinton; Piper, Derek Evan; Shan, Bei; Shen, Wenyan; Chan, Joyce Chi Yee; King, Chadwick Terence; Ketchem, Randal Robert; Mehlin, Christopher; Carabeo, Teresa Arazas; Cao, Qiong
    United States Patent Application: 20120027765
    PDF of patent application.

  41. ANTIGEN BINDING PROTEINS TO PROPROTEIN CONVERTASE SUBTILISIN KEXIN TYPE 9 (PCSK9)
    Filing Date: October 3, 2011
    Publication Date: January 26, 2012
    Inventors: Jackson, Simon Mark; Walker, Nigel Pelham Clinton; Piper, Derek Evan; Shan, Bei; Shen, Wenyan; Chan, Joyce Chi Yee; King, Chadwick Terence; Ketchem, Randal Robert; Mehlin, Christopher; Carabeo, Teresa Arazas; Cao, Qiong
    United States Patent Application: 20120020976
    PDF of patent application.

  42. ANTIGEN BINDING PROTEINS TO PROPROTEIN CONVERTASE SUBTILISIN KEXIN TYPE 9 (PCSK9)
    Filing Date: October 3, 2011
    Publication Date: January 26, 2012
    Inventors: Jackson, Simon Mark; Walker, Nigel Pelham Clinton; Piper, Derek Evan; Shan, Bei; Shen, Wenyan; Chan, Joyce Chi Yee; King, Chadwick Terence; Ketchem, Randal Robert; Mehlin, Christopher; Carabeo, Teresa Arazas; Cao, Qiong
    United States Patent Application: 20120020975
    PDF of patent application.

  43. IL-1 FAMILY VARIANTS
    Filing Date: September 10, 2007
    Publication Date: January 26, 2012
    Inventors: Sims, John E.; Renshaw, Blair R.; Gabel, Christopher; Towne, Jennifer E.; Ketchem, Randal R.
    United States Patent Application: 20120020918
    PDF of patent application.

  44. ANTI-HEPCIDIN ANTIBODIES AND METHODS OF USE
    Filing Date: April 28, 2009
    Publication Date: June 23, 2011
    Inventors: Foltz, Ian; Gallo, Michael; Cooke, Keegan; Ketchem, Randal R.; Mehlin, Christopher
    United States Patent Application: 20110150888
    PDF of patent application.

  45. ANTIGEN BINDING PROTEINS TO PROPROTEIN CONVERTASE SUBTILISIN KEXIN TYPE 9 (PCSK9)
    Filing Date: October 12, 2010
    Publication Date: February 3, 2011
    Inventors: Jackson, Simon Mark; Walker, Nigel Pelham Clinton; Piper, Derek Evan; Shan, Bei; Shen, Wenyan; Chan, Joyce Chi Yee; King, Chadwick Terence; Ketchem, Randal Robert; Mehlin, Christopher; Carabeo, Teresa Arazas; Cao, Qiong
    United States Patent Application: 20110027287
    PDF of patent application.

  46. TWEAK Receptor
    Filing Date: October 6, 2010
    Publication Date: January 27, 2011
    Inventors: Kim, Kristine M.; Wiley, Steven R.; Ketchem, Randal R.; Fanslow III, William C.
    United States Patent Application: 20110020267
    PDF of patent application.

  47. Polypeptides and Antibodies
    Filing Date: April 2, 2009
    Publication Date: September 10, 2009
    Inventors: Gliniak, Brian; Yang, Xiao-Dong; Wong-Madden, Sharon; Foltz, Ian; Feng, Xiao; Fitch, Alison; Foster, Stephen; Ketchem, Randal R.
    United States Patent Application: 20090226438
    PDF of patent application.

  48. ANTIGEN BINDING PROTEINS TO PROPROTEIN CONVERTASE SUBTILISIN KEXIN TYPE 9 (PCSK9)
    Filing Date: August 22, 2008
    Publication Date: June 4, 2009
    Inventors: Jackson, Simon Mark; Walker, Nigel Pelham Clinton; Piper, Derek Evan; Shan, Bei; Shen, Wenyan; Chan, Joyce Chi Yee; King, Chadwick Terence; Ketchem, Randal Robert; Mehlin, Christopher; Carabeo, Teresa Arazas; Cao, Qiong
    United States Patent Application: 20090142352
    PDF of patent application.

  49. TWEAK RECEPTOR
    Filing Date: January 16, 2009
    Publication Date: May 28, 2009
    Inventors: Kim, Kristine M.; Wiley, Steven R.; Ketchem, Randal R.; Fanslow, III, William C.
    United States Patent Application: 20090137036
    PDF of patent application.

  50. IL-1 family variants
    Filing Date: September 10, 2007
    Publication Date: October 2, 2008
    Inventors: Sims, John E.; Renshaw, Blair R.; Gabel, Christopher; Towne, Jennifer E.; Ketchem, Randal R.
    United States Patent Application: 20080241096
    PDF of patent application.

  51. Erythropoietin receptor agonists
    Filing Date: April 13, 2007
    Publication Date: May 29, 2008
    Inventors: Borges, Luis G.; Ketchem, Randal R.; Lim, Ai Ching; Mehlin, Christopher; Zhou, Hongxing
    United States Patent Application: 20080124340
    PDF of patent application.

  52. Polypeptides and antibodies
    Filing Date: August 28, 2006
    Publication Date: August 2, 2007
    Inventors: Gliniak, Brian; Yang, Xiao-Dong; Wong-Madden, Sharon; Foltz, Ian; Feng, Xiao; Fitch, Alison; Foster, Stephen; Ketchem, Randal R.
    United States Patent Application: 20070179086
    PDF of patent application.

  53. Cytokine polypeptides
    Filing Date: November 20, 2006
    Publication Date: April 12, 2007
    Inventors: Baum, Peter R.; Mosley, Bruce A.; Ketchem, Randal R.; Taylor, Scott L.
    United States Patent Application: 20070081973
    PDF of patent application.

  54. Human cytokine and alpha-helix-containing polypeptides
    Filing Date: December 6, 2006
    Publication Date: March 29, 2007
    Inventors: Baum, Peter R.; Ketchem, Randal R.; DuBose, Robert F.; Wiley, Steven R.; Kerkof, Keith N.
    United States Patent Application: 20070072249
    PDF of patent application.

  55. Human and murine cytokine polypeptides
    Filing Date: July 7, 2005
    Publication Date: May 25, 2006
    Inventors: Baum, Peter R.; Mosley, Bruce A.; Ketchem, Randal R.
    United States Patent Application: 20060110772
    PDF of patent application.

  56. TWEAK receptor
    Filing Date: October 22, 2004
    Publication Date: September 22, 2005
    Inventors: Kim, Kristine M.; Wiley, Steven R.; Ketchem, Randal R.; Fanslow, William C. III
    United States Patent Application: 20050208046
    PDF of patent application.

  57. Human and murine cytokine polypeptides
    Filing Date: October 2, 2002
    Publication Date: July 17, 2003
    Inventors: Baum, Peter R.; Mosley, Bruce A.; Ketchem, Randal R.
    United States Patent Application: 20030134306
    PDF of patent application.

  58. Cytokine polypeptides
    Filing Date: May 8, 2002
    Publication Date: June 5, 2003
    Inventors: Baum, Peter R.; Mosley, Bruce A.; Ketchem, Randal R.; Taylor, Scott L.
    United States Patent Application: 20030104579
    PDF of patent application.


Invited Talks:

  1. Structured Data Driven Approaches Toward Reducing the Cost of Biotherapeutics
    2017 Grand Challenges Meeting
    October 3, 2017

  2. Computational Design and High Throughput Characterization to Predict and Repair Molecular Attributes
    Protein Engineering Summit (PEGS) 2017
    May 4, 2017

  3. Therapeutic Antibody Designs for Efficacy and Manufacturability
    LabKey User Group Meeting 2016
    Recorded talk
    October 6, 2016

  4. Antibody and Protein Engineering: Developing Therapeutics
    FSU Kasha Award Seminar
    April 15, 2014

  5. Antibody Optimization Before the Storm
    PepTalk 2013
    January 23, 2013

  6. Mitigation of Monoclonal Antibody Viscosity by Modification of Protein Surface Charge
    Protein Engineering Summit (PEGS) 2012
    April 30, 2012

  7. Mediating Antibody Viscosity
    Chemical Computing Group User Group Meeting
    June 3, 2010

  8. Pacific Lutheran University
    Mining the Human Genome Using Protein Structure Homology
    September 11, 2002

  9. Western Washington University
    Mining the Human Genome Using Protein Structure Homology
    June 5, 2002


Ph.D. Dissertation:

Structural Determination and Refinement of the Gramicidin A Transmembrane Channel as Studied by Solid State Nuclear Magnetic Resonance Spectroscopy
Randal R. Ketchem
FSU call number QP551.K47 1995.
PDF Version.


Photography:

  1. Title: Sperry Peak, Fresh Snow
    Image on RRKPhoto.com
    Outdoor Photographer, Favorite Places, November, 2011

  2. Title:Sunrise on Sea Stacks, Reflected, Oceanside, Oregon
    Image on RRKPhoto.com
    Outdoor Photographer, 2009 Calendar

  3. Title: Fall Color on Coal Lake #7
    Image on RRKPhoto.com
    Outdoor Photographer, Favorite Places, March, 2006

Education

Florida State University Tallahassee, FL

Ph.D. Molecular Biophysics Aug 1989 - Dec 1995

Ph.D. in Molecular Biophysics at the Florida State University and National High Magnetic Field Laboratory working on Solid State Nuclear Magnetic Resonance Spectroscopy and computational methods for the structure determination of the Gramicidin A transmembrane channel. Advisor Timothy A. Cross.

University of West Florida Pensacola, FL

B.S. Chemistry/Biochemistry Aug 1987 - Aug 1989

While obtaining my B.S. in Chemistry I worked in the research lab of Dr. John Riehm, performing protein purification using gel columns and HPLC, and performing solid phase peptide synthesis.

Okaloosa Walton Junior College Niceville, FL

A.A. Jun 1983 - Aug 1987

For my AA I focused on Biology and general science, taking courses across the spectrum of the sciences including Chemistry, Biology and Physics.

Employment History

Just Biotherapeutics Seattle, WA

Vice President of Molecular Design Nov 2014 - Present

Molecular Design encompasses all design, analysis, and evaluation of biologics-based therapeutics.

Amgen Inc Seattle, WA

Director of Research Jan 2011 - Nov 2014

Lead the Protein and Antibody Optimization team, responsible for engineering all biologics that come through Amgen's pipeline. My research direction is focused on computational structural biology while also applying my skills to broader platform review and direction. Working in areas of antibody design, epitope mapping, molecular assessment, stability engineering, construct design, protein engineering and serving on therapeutic area teams to lead target development.

Amgen Inc Seattle, WA

Principal Scientist Jul 2002 - Jan 2011

My move to Amgen was due to Immunex being purchased by Amgen. My research direction is focused on computational structural biology while also applying my skills to broader platform review and direction. Working in areas of antibody epitope mapping, molecular assessment, stability engineering, construct design, protein engineering and serving on therapeutic area teams to lead target development.

Immunex Corporation Seattle, WA

Scientist Nov 1997 - Jul 2002

Computational structural biology involving protein structure determination, analysis and design, protein target discovery, and protein engineering.

The Scripps Research Institute La Jolla, CA

Postdoctoral Fellow Feb 1996 - Nov 1997

Postdoctoral research in Molecular Biology at The Scripps Research Institute working on High Resolution Nuclear Magnetic Resonance Spectroscopy and computational methods for the structure determination of calcium loaded calcyclin and small molecule binders to the minor groove of DNA.

Florida State University Tallahassee, FL

Postdoctoral Fellow Dec 1995 - Feb 1996

Continued as a Postdoctoral Fellow under my Ph.D. advisor, Timothy A. Cross.

Hobbies
Photography (Randal R. Ketchem Photography), Hiking
References
Available on request