Structural Determination and Refinement of the Gramicidin A Transmembrane Channel as Studied by Solid State Nuclear Magnetic Resonance Spectroscopy
Randal R. Ketchem
FSU call number QP551.K47 1995.
Order a copy at ProQuest.
PDF Version.

1. A Central Nervous System-Restricted Isoform of the Interleukin-1 Receptor Accessory Protein Modulates Neuronal Responses to Interleukin-1
   Dirk E. Smith, Brian P. Lipsky, Chris Russell, Randal R. Ketchem, Jacqueline Kirchner, Kelly Hensley, Yangyang Huang, Wilma J. Friedman, Vincent Boissonneault, Marie-Michèle Plante, Serge Rivest and John E. Sims
   Immunity 2009, v20, n6, 817-831

2. Electrophoretic evidence for the presence of structural isoforms specific for the IgG2 isotype
   Amy Guo, Mei Han, Theresa Martinez, Randal R. Ketchem, Shawn Novick, Claudia Jochheim, Alain Balland
   Electrophoresis 2008, 29, 2550-2556

3. A role for the MHC class I-like Mill molecules in nutrient metabolism and wound healing
   Brian A. Rabinovich, Randal R. Ketchem, Martin Wolfson, Lynn Goldstein, Marylin Skelly and David Cosman
   Immunology and Cell Biology (2008) 86, 489-496

4. Disulfide Connectivity of Human Immunoglobulin G2 Structural Isoforms
   Theresa Martinez, Amy Guo, Martin J. Allen, Mei Han, Danielle Pace, Jay Jones, Ron Gillespie, Randal R. Ketchem, Yuling Zhang, and Alain Balland
   Biochemistry (2008) 47, 7496-7508

5. Biophysical Characterization of Structural Properties and Folding of Interleukin-1 Receptor Antagonist
   Ramil F. Latypov, Timothy S. Harvey, Dingjiang Liu, Pavel V. Bondarenko, Tadahiko Kohno, Roger A. Fachini II, Robert D. Rosenfeld, Randal R. Ketchem, David N. Brems, and Andrei A. Raibekas
   Journal of Molecular Biology (2007) 368, 1187-1201

6. A Single Amino Acid Difference between Human and Monkey Interleukin (IL)-1B Dictates Effective Binding to Soluble Type II IL-1 Receptor
   Dirk E. Smith, Randal R. Ketchem, Heather Moore, Zachary Anderson, Blair R. Renshaw, Della J. Friend, and John E. Sims
   The Journal of Biological Chemistry, Vol. 277, No. 49, Issue of December 6, pp. 47619-47625, 2002

7. Biophysical Characterization of a Soluble CD40 Ligand (CD154) Coiled-Coil Trimer: Evidence of a Reversible Acid-Denatured Molten Globule
   James E. Matsuura, Arvia E. Morris, Randal R. Ketchem, Emory H. Braswell, Ralph Klinke, Wayne R. Gombotz, and Richard L. Remmele, Jr.
   Archives of Biochemistry and Biophysics, Vol. 392, No. 2, August 15, pp. 208-218, 2001

8. Four New Members Expand the Interleukin-1 Superfamily
   Dirk E. Smith, Blair R. Renshaw, Randal R. Ketchem, Marek Kubin, Kirsten E. Garka, and John E. Sims
   The Journal of Biological Chemistry, Vol. 275, No. 2, Issue of January 14, pp. 1169-1175, 2000

9. Binding-Induced Activation of DNA Alkylation by Duocarmycin SA: Insights from the Structure of an Indole Derivative-DNA Adduct
   Jason R. Schnell, Randal R. Ketchem, Dale L. Boger, and Walter J. Chazin
   Journal of the American Chemical Society 1999, 121, 5645-5652

10. The three-dimensional structure of Ca2+-bound calcyclin: implications for Ca2+-signal transduction by S100 proteins
    Mallika Sastry, Randal R Ketchem, Orlando Crescenzi, Christoph Weber, Michael J Lubienski, Hiroyoshi Hidaka and Walter J Chazin
    Structure 15 February 1998, 6:223-231

11. High-resolution polypeptide structure in a lamellar phase lipid environment from solid state NMR derived orientational constraints
    RR Ketchem, B Roux and TA Cross
    Structure 15 December 1997, 5:1655-1669

12. Macromolecular structural elucidation with solid-state NMR-derived orientational constraints
    R. R. Ketchem, K. -C. Lee, S. Huo, and T. A. Cross
    Journal of Biomolecular NMR, 8 (1996) 1-14

13. Conformational trapping in a membrane environment: A regulatory mechanism for protein activity?
    S. Arumugam, S. Pascal, C. L. North, W. Hu, K-C. Lee, M. Cotten, R. R. Ketchem, F. Xu, M. Brenneman, F. Kovacs, F. Tian, A. Wang, S. Huo, and T. A. Cross
    Proceedings of the National Academy of Sciences of the United States of America, Vol. 93, pp. 5872-5876, June 1996

14. High-Resolution Conformation of Gramicidin A in a Lipid Bilayer by Solid-State NMR
    R. R. Ketchem, W. Hu, T. A. Cross
    Science 261, 1457 (1993)

Invited:

1. Computational Refinement Through Solid State NMR and Energy Constraints of a Membrane Bound Polypeptide.
   R.R. Ketchem, B. Roux and T.A. Cross
   Biological Membranes: A Molecular Perspective from Computation and Experiment

2. Structure and dynamics from solid state NMR spectroscopy
   RR Ketchem, W Hu, F Tian and TA Cross
   Structure, 15 August 1994, 2:699-701

3. High Resolution Polypeptide Structure in Anisotropic Environments: The Gramicidin Channel
   T.A. Cross, R.R. Ketchem, W. Hu, K.C. Lee, N.D. Lazo and S. Huo
   Proceedings of the Conference on Stable Isotope Applications in Biomolecular Structure and Mechanisms, 1994

4. Structure and Dynamics of a Membrane Bound Polypeptide
   T.A. Cross, R.R. Ketchem, W. Hu, K.C. Lee, N.D. Lazo and C.L. North
   Bulletin of Magnetic Resonance 14(1-4): 96-101, 1993

Patents Issued:

1. TRAIL Receptor-2 Polypeptides and antibodies
   Published: August 2, 2007
   Issued: April 21, 2009
   Gliniak, Brian; Yang, Xiao-Dong; Wong-Madden, Sharon; Foltz, Ian; Feng, Xiao; Fitch, Alison; Foster, Stephen; Ketchem, Randal R.
   United States Patent 7,521,048
   PDF of issued patent.

2. TWEAK receptor
   Published: September 22, 2005
   Issued: February 24, 2009
   Kim, Kristine M.; Wiley, Steven R.; Ketchem, Randal R.; Fanslow, William C. III
   United States Patent 7,495,086
   PDF of issued patent.

Patents Published:

1. Antigen Binding Proteins to Proprotein Convertase Subtilisin Kexin Type 9 (PCSK9)
   Application number: 20090142352
   Filing Date: August 22, 2008
   Inventors: Simon Mark Jackson, Nigel Pelham Clinton Walker, Derek Evan Piper, Bei Shan, Wenyan Shen, Joyce Chi Yee Chan, Chadwick Terence King, Randal Robert Ketchem, Christopher Mehlin, Teresa Arazas Carabeo, Qiong Cao

2. Erythropoietin receptor agonists
   Application number: 11/786,879
   Publication number: US 2008/0124340 A1
   Filing Date: April 13, 2007
   Inventors: Luis G. Borges, Randal R. Ketchem, Ai Ching Lim, Christopher Mehlin, Hongxing Zhou

3. IL-1 Family Variants
   Application number: 20080241096
   Filing Date: October 2, 2008
   Inventors: John E. Sims, Blair R. Renshaw, Christopher Gabel, Jennifer E. Towne, Randal R. Ketchem

4. Cytokine polypeptides
   Application number: 11/602,056
   Publication number: US 2007/0081973 A1
   Filing date: Nov 20, 2006
   Inventors: Peter R. Baum, Bruce A. Mosley, Randal R. Ketchem, Scott L. Taylor

5. Human cytokine and alpha-helix-containing polypeptides
   Application number: 11/634,751
   Publication number: US 2007/0072249 A1
   Filing date: Dec 6, 2006
   Inventors: Peter R. Baum, Randal R. Ketchem, Robert F. DuBose, Steven R. Wiley, Keith N. Kerkof

6. Human and murine cytokine polypeptides
   Application number: 11/177,635
   Publication number: US 2006/0110772 A1
   Filing date: Jul 7, 2005
   Inventors: Peter R. Baum, Bruce A. Mosley, Randal R. Ketchem

7. Human and murine cytokine polypeptides
   Application number: 10/263,568
   Publication number: US 2003/0134306 A1
   Filing date: Oct 2, 2002
   Inventors: Peter R. Baum, Bruce A. Mosley, Randal R. Ketchem

8. Cytokine polypeptides
   Application number: 10/142,717
   Publication number: US 2003/0104579 A1
   Filing date: May 8, 2002
   Inventors: Peter R. Baum, Bruce A. Mosley, Randal R. Ketchem, Scott L. Taylor

Photography:

1. Sunrise on Sea Stacks, Reflected, Oceanside, Oregon
   Randal R. Ketchem
   Outdoor Photographer, 2009 Calendar

2. Coal Lake, Washington
   Randal R. Ketchem
   Outdoor Photographer, Favorite Places, March, 2006