Randal R. Ketchem's Publications


Peer Reviewed:

  1. Chemical Modifications in Therapeutic Protein Aggregates Generated under Different Stress Conditions
    Quanzhou Luo, Marisa K. Joubert, Riki Stevenson, Randal R. Ketchem, Linda O. Narhi, and Jette Wypych
    The Journal of Biological Chemistry, v286, 25134-25144, 2011

  2. In Vivo Crystallization of Human IgG in the Endoplasmic Reticulum of Engineered Chinese Hamster Ovary (CHO) Cells
    Haruki Hasegawa, John Wendling, Feng He, Egor Trilisky, Riki Stevenson, Heather Franey, Francis Kinderman, Gary Li, Deirdre Murphy Piedmonte, Timothy Osslund, Min Shen, Randal R. Ketchem
    The Journal of Biological Chemistry, v286, 19917-19931, 2011

  3. Diverse functions of reactive cysteines facilitate unique biosynthetic processes of aggregate-prone interleukin-31
    Min Shen, Sophia Siu, Samantha Byrd, Kurt H. Edelmann, Neha Patel, Randal R. Ketchem, Christopher Mehlin, Heather A. Arnett, Haruki Hasegawa
    Experimental Cell Research, v317, 976-993, 2011

  4. Histidine Residue Mediates Radical-induced Hinge Cleavage of Human IgG1
    Zac Yates, Guna Kannan, Hongxing Zhou, Zhonghua Hu, Zhi Liu, Randal R. Ketchem, and Boxu Yan
    J. Biol. Chem., v285, n24, 18662-18671, 2010

  5. Glutamine-linked and Non-consensus Asparagine-linked Oligosaccharides Present in Human Recombinant Antibodies Define Novel Protein Glycosylation Motifs
    John F. Valliere-Douglass, Catherine M. Eakin, Alison Wallace, Randal R. Ketchem, Wesley Wang, Michael J. Treuheit, and Alain Balland
    J. Biol. Chem., v285, n21, 16012-16022, 2010

  6. A Diversity of Antibody Epitopes can Induce Signaling through the Erythropoietin Receptor
    Ai Ching Lim, Randal R Ketchem, Luis Borges, Teresa Carabeo, Jane Carter, Joseph E. Hoover, Zhonghua Hu, Michael Wittekind, Hongxing Zhou and Christopher Mehlin
    Biochemistry, v49, 3797-3804, 2010

  7. A Central Nervous System-Restricted Isoform of the Interleukin-1 Receptor Accessory Protein Modulates Neuronal Responses to Interleukin-1
    Dirk E. Smith, Brian P. Lipsky, Chris Russell, Randal R. Ketchem, Jacqueline Kirchner, Kelly Hensley, Yangyang Huang, Wilma J. Friedman, Vincent Boissonneault, Marie-Michèle Plante, Serge Rivest and John E. Sims
    Immunity, v30, n6, 817-831, 2009

  8. Electrophoretic evidence for the presence of structural isoforms specific for the IgG2 isotype
    Amy Guo, Mei Han, Theresa Martinez, Randal R. Ketchem, Shawn Novick, Claudia Jochheim, Alain Balland
    Electrophoresis, 29, 2550-2556, 2008

  9. A role for the MHC class I-like Mill molecules in nutrient metabolism and wound healing
    Brian A. Rabinovich, Randal R. Ketchem, Martin Wolfson, Lynn Goldstein, Marylin Skelly and David Cosman
    Immunology and Cell Biology, v86, 489-496, 2008

  10. Disulfide Connectivity of Human Immunoglobulin G2 Structural Isoforms
    Theresa Martinez, Amy Guo, Martin J. Allen, Mei Han, Danielle Pace, Jay Jones, Ron Gillespie, Randal R. Ketchem, Yuling Zhang, and Alain Balland
    Biochemistry, v47, 7496-7508, 2008

  11. Biophysical Characterization of Structural Properties and Folding of Interleukin-1 Receptor Antagonist
    Ramil F. Latypov, Timothy S. Harvey, Dingjiang Liu, Pavel V. Bondarenko, Tadahiko Kohno, Roger A. Fachini II, Robert D. Rosenfeld, Randal R. Ketchem, David N. Brems, and Andrei A. Raibekas
    Journal of Molecular Biology, v368, 1187-1201, 2007

  12. A Single Amino Acid Difference between Human and Monkey Interleukin (IL)-1B Dictates Effective Binding to Soluble Type II IL-1 Receptor
    Dirk E. Smith, Randal R. Ketchem, Heather Moore, Zachary Anderson, Blair R. Renshaw, Della J. Friend, and John E. Sims
    The Journal of Biological Chemistry, v277, n49, 47619-47625, 2002

  13. Biophysical Characterization of a Soluble CD40 Ligand (CD154) Coiled-Coil Trimer: Evidence of a Reversible Acid-Denatured Molten Globule
    James E. Matsuura, Arvia E. Morris, Randal R. Ketchem, Emory H. Braswell, Ralph Klinke, Wayne R. Gombotz, and Richard L. Remmele, Jr.
    Archives of Biochemistry and Biophysics, v392, n2, 208-218, 2001

  14. Four New Members Expand the Interleukin-1 Superfamily
    Dirk E. Smith, Blair R. Renshaw, Randal R. Ketchem, Marek Kubin, Kirsten E. Garka, and John E. Sims
    The Journal of Biological Chemistry, v275, n2, 1169-1175, 2000

  15. Binding-Induced Activation of DNA Alkylation by Duocarmycin SA: Insights from the Structure of an Indole Derivative-DNA Adduct
    Jason R. Schnell, Randal R. Ketchem, Dale L. Boger, and Walter J. Chazin
    Journal of the American Chemical Society, v121, 5645-5652, 1999

  16. The three-dimensional structure of Ca2+-bound calcyclin: implications for Ca2+-signal transduction by S100 proteins
    Mallika Sastry, Randal R Ketchem, Orlando Crescenzi, Christoph Weber, Michael J Lubienski, Hiroyoshi Hidaka and Walter J Chazin
    Structure, v6, 223-231, 1998

  17. High-resolution polypeptide structure in a lamellar phase lipid environment from solid state NMR derived orientational constraints
    RR Ketchem, B Roux and TA Cross
    Structure, v5, 1655-1669, 1997

  18. Macromolecular structural elucidation with solid-state NMR-derived orientational constraints
    R. R. Ketchem, K. -C. Lee, S. Huo, and T. A. Cross
    Journal of Biomolecular NMR, v8,1-14, 1996

  19. Conformational trapping in a membrane environment: A regulatory mechanism for protein activity?
    S. Arumugam, S. Pascal, C. L. North, W. Hu, K-C. Lee, M. Cotten, R. R. Ketchem, F. Xu, M. Brenneman, F. Kovacs, F. Tian, A. Wang, S. Huo, and T. A. Cross
    Proceedings of the National Academy of Sciences of the United States of America, v93, 5872-5876, 1996

  20. High-Resolution Conformation of Gramicidin A in a Lipid Bilayer by Solid-State NMR
    R. R. Ketchem, W. Hu, T. A. Cross
    Science, v261, 1457-1460, 1993


Invited:

  1. Computational Refinement Through Solid State NMR and Energy Constraints of a Membrane Bound Polypeptide.
    R.R. Ketchem, B. Roux and T.A. Cross
    Biological Membranes: A Molecular Perspective from Computation and Experiment, K.M. Merz and B. Roux, Birkhauser Boston, 1996

  2. Structure and dynamics from solid state NMR spectroscopy
    RR Ketchem, W Hu, F Tian and TA Cross
    Structure, v2, 699-701, 1994

  3. High Resolution Polypeptide Structure in Anisotropic Environments: The Gramicidin Channel
    T.A. Cross, R.R. Ketchem, W. Hu, K.C. Lee, N.D. Lazo and S. Huo
    Proceedings of the Conference on Stable Isotope Applications in Biomolecular Structure and Mechanisms, 1994

  4. Structure and Dynamics of a Membrane Bound Polypeptide
    T.A. Cross, R.R. Ketchem, W. Hu, K.C. Lee, N.D. Lazo and C.L. North
    Bulletin of Magnetic Resonance v14, 96-101, 1993


Patents Issued:

  1. IL-1F6 Polypeptides
    Filed: September 10, 2007
    Issued: October 11, 2011
    Sims, John E.; Renshaw, Blair R.; Gabel, Christopher; Towne, Jennifer E.; Ketchem, Randal R.
    United States Patent 8,034,771
    PDF of issued patent.

  2. TWEAK receptor
    Filed: January 16, 2009
    Issued: November 9, 2010
    Kim, Kristine M.; Wiley, Steven R.; Ketchem, Randal R.; Fanslow, III, William C.
    United States Patent 7,829,675
    PDF of issued patent.

  3. TRAIL Receptor-2 Polypeptides and antibodies
    Published: August 2, 2007
    Issued: April 21, 2009
    Gliniak, Brian; Yang, Xiao-Dong; Wong-Madden, Sharon; Foltz, Ian; Feng, Xiao; Fitch, Alison; Foster, Stephen; Ketchem, Randal R.
    United States Patent 7,521,048
    PDF of issued patent.

  4. TWEAK receptor
    Published: September 22, 2005
    Issued: February 24, 2009
    Kim, Kristine M.; Wiley, Steven R.; Ketchem, Randal R.; Fanslow, William C. III
    United States Patent 7,495,086
    PDF of issued patent.


Patents Published:

  1. ANTI-HEPCIDIN ANTIBODIES AND METHODS OF USE
    United States Patent Application: 20110150888
    Filing Date: April 28, 2009
    Publication Date: June 23, 2011
    Inventors: Foltz, Ian; Gallo, Michael; Cooke, Keegan; Ketchem, Randal R.; Mehlin, Christopher
    PDF of patent application.

  2. ANTIGEN BINDING PROTEINS TO PROPROTEIN CONVERTASE SUBTILISIN KEXIN TYPE 9 (PCSK9)
    United States Patent Application: 20110027287
    Filing Date: October 12, 2010
    Publication Date: February 3, 2011
    Inventors: Jackson, Simon Mark; Walker, Nigel Pelham Clinton; Piper, Derek Evan; Shan, Bei; Shen, Wenyan; Chan, Joyce Chi Yee; King, Chadwick Terence; Ketchem, Randal Robert; Mehlin, Christopher; Carabeo, Teresa Arazas; Cao, Qiong
    PDF of patent application.

  3. TWEAK Receptor
    United States Patent Application: 20110020267
    Filing Date: October 6, 2010
    Publication Date: January 27, 2011
    Inventors: Kim, Kristine M.; Wiley, Steven R.; Ketchem, Randal R.; Fanslow III, William C.
    PDF of patent application.

  4. Polypeptides and Antibodies
    United States Patent Application: 20090226438
    Filed: April 2, 2009
    Inventors: Gliniak, Brian; Yang, Xiao-Dong; Wong-Madden, Sharon; Foltz, Ian; Feng, Xiao; Fitch, Alison; Foster, Stephen; Ketchem, Randal R.

  5. TWEAK RECEPTOR
    United States Patent Application: 20090137036
    Filed: January 16, 2009
    Inventors: KIM, KRISTINE M.; Wiley, Steven R.; Ketchem, Randal R.; Fanslow, III, William C.

  6. ANTIGEN BINDING PROTEINS TO PROPROTEIN CONVERTASE SUBTILISIN KEXIN TYPE 9 (PCSK9)
    United States Patent Application: 20090142352
    Filed: August 22, 2008
    Inventors: Jackson, Simon Mark; Walker, Nigel Pelham Clinton; Piper, Derek Evan; Shan, Bei; Shen, Wenyan; Chan, Joyce Chi Yee; King, Chadwick Terence; Ketchem, Randal Robert; Mehlin, Christopher; Carabeo, Teresa Arazas; Cao, Qiong

  7. IL-1 family variants
    United States Patent Application: 20080241096
    Filed: September 10, 2007
    Inventors: Sims, John E.; Renshaw, Blair R.; Gabel, Christopher; Towne, Jennifer E.; Ketchem, Randal R.

  8. Erythropoietin receptor agonists
    United States Patent Application: 20080124340
    Filed: April 13, 2007
    Inventors: Borges, Luis G.; Ketchem, Randal R.; Lim, Ai Ching; Mehlin, Christopher; Zhou, Hongxing

  9. Human cytokine and alpha-helix-containing polypeptides
    United States Patent Application: 20070072249
    Filed: December 6, 2006
    Inventors: Baum, Peter R.; Ketchem, Randal R.; DuBose, Robert F.; Wiley, Steven R.; Kerkof, Keith N.

  10. Cytokine polypeptides
    United States Patent Application: 20070081973
    Filed: November 20, 2006
    Inventors: Baum, Peter R.; Mosley, Bruce A.; Ketchem, Randal R.; Taylor, Scott L.

  11. Polypeptides and antibodies
    United States Patent Application: 20070179086
    Filed: August 28, 2006
    Inventors: Gliniak, Brian; Yang, Xiao-Dong; Wong-Madden, Sharon; Foltz, Ian; Feng, Xiao; Fitch, Alison; Foster, Stephen; Ketchem, Randal R.

  12. Human and murine cytokine polypeptides
    United States Patent Application: 20060110772
    Filed: July 7, 2005
    Inventors: Baum, Peter R.; Mosley, Bruce A.; Ketchem, Randal R.

  13. TWEAK receptor
    United States Patent Application: 20050208046
    Filed: October 22, 2004
    Inventors: Kim, Kristine M.; Wiley, Steven R.; Ketchem, Randal R.; Fanslow, William C. III

  14. Human and murine cytokine polypeptides
    United States Patent Application: 20030134306
    Filed: October 2, 2002
    Inventors: Baum, Peter R.; Mosley, Bruce A.; Ketchem, Randal R.

  15. Cytokine polypeptides
    United States Patent Application: 20030104579
    Filed: May 8, 2002
    Inventors: Baum, Peter R.; Mosley, Bruce A.; Ketchem, Randal R.; Taylor, Scott L.


Invited Talks:

  1. Mediating Antibody Viscosity
    Chemical Computing group User Group Meeting
    June 3, 2010

  2. Mining the Human Genome Using Protein Structure Homology
    Pacific Lutheran University
    September 11, 2002

  3. Mining the Human Genome Using Protein Structure Homology
    Western Washington University
    June 5, 2002


Ph.D. Dissertation:

Structural Determination and Refinement of the Gramicidin A Transmembrane Channel as Studied by Solid State Nuclear Magnetic Resonance Spectroscopy
Randal R. Ketchem
FSU call number QP551.K47 1995.
PDF Version.


Photography:

  1. Sperry Peak, Fresh Snow
    Randal R. Ketchem
    Outdoor Photographer, Favorite Places, November, 2011

  2. Sunrise on Sea Stacks, Reflected, Oceanside, Oregon
    Randal R. Ketchem
    Outdoor Photographer, 2009 Calendar

  3. Coal Lake, Washington
    Randal R. Ketchem
    Outdoor Photographer, Favorite Places, March, 2006